Base excision repair
| PAG Title | Base excision repair |
| PAG ID | WAG001216 |
| Type | P |
| Source Link |  KEGG |
| Publication Reference | NA |
| PAG Description | Base excision repair (BER) is the predomint D damage repair pathway for the processing of small base lesions, derived from oxidation and alkylation damages. BER is normally defined as D repair initiated by lesion-specific D glycosylases and completed by either of the two sub-pathways: short-patch BER where only one nucleotide is replaced and long-patch BER where 2-13 nucleotides are replaced. Each sub-pathway of BER relies on the formation of protein complexes that assemble at the site of the D lesion and facilitate repair in a coordited fashion. This process of complex formation appears to provide an increase in specificity and efficiency to the BER pathway, thereby facilitating the maintence of genome integrity by preventing the accumulation of highly toxic repair intermediates. |
| Species | Homo sapiens |
| nCoCo Score | 1,801 |
| Base PAG ID | WAG001216 |
| Human Phenotyte Annotation | |
| Curator | PAGER curation team |
| Curator Contact | PAGER-contact@googlegroups.com |
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